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Related Experiment Video

Updated: Jun 17, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

Fluorescence lymph node mapping in living mice using quantum dots and a compression technique.

Yusuke Inoue1, Shigeru Kiryu, Makoto Watanabe

  • 1Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. inoueys-tky@umin.ac.jp

Journal of Fluorescence
|January 19, 2010
PubMed
Summary
This summary is machine-generated.

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Non-invasive fluorescence imaging with quantum dots effectively maps lymphatic drainage, visualizing deep abdominal lymph nodes in mice. A simple abdominal compression technique significantly enhances visualization of these critical nodes.

Area of Science:

  • Oncology
  • Immunology
  • Medical Imaging

Background:

  • The lymphatic system is crucial in oncology and immunology.
  • In vivo fluorescence imaging is vital for assessing lymphatic drainage.

Purpose of the Study:

  • To investigate non-invasive fluorescence lymph node mapping in mice.
  • To assess deep abdominal lymph nodes and the effect of abdominal compression.

Main Methods:

  • Subcutaneous injection of quantum dots into mouse rear footpads.
  • Time-course assessment of fluorescent signals.
  • Comparison of lymph node visualization with and without abdominal compression.

Main Results:

  • Popliteal, sacral, iliac, and renal lymph nodes were successfully delineated.

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Related Experiment Videos

Last Updated: Jun 17, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

  • Lymph node signals peaked at 3 hours post-injection.
  • Abdominal compression significantly improved visualization of deep iliac lymph nodes, making them visible at lower quantum dot doses.

    • Conclusions:

    • Quantum dot-based fluorescence lymph node mapping enables visualization of deep abdominal lymph nodes in intact mice.
    • A simple abdominal compression technique enhances the detection of deep lymphatic structures.