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Updated: Jun 17, 2026
Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
Published on: July 6, 2022
Pathology and biology associated with the fragile FHIT gene and gene product
Joshua C Saldivar1, Hidetaka Shibata, Kay Huebner
1Integrated Biomedical Science Graduate Program, Ohio State University Medical Center, Columbus, Ohio, USA.
Abstract:
More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions are considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies.
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