Related Experiment Video
Updated: Jun 17, 2026
11:02
Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
Published on: May 27, 2016
ABCC2/Abcc2: a multispecific transporter with dominant excretory functions
Katalin Jemnitz1, Krisztina Heredi-Szabo, Judit Janossy
1Chemical Research Center, Institute of Biomolecular Chemistry, HAS, Budapest, Hungary.
Drug Metabolism Reviews
|January 20, 2010
Summary
The ABCC2 transporter protein is crucial at physiological barriers, handling diverse molecules like bilirubin and drugs. Mutations in ABCC2 cause Dubin-Johnson syndrome, leading to hyperbilirubinemia.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- The ABCC2/Abcc2 transporter, also known as MRP2/Mrp2, is located in the apical membranes of key physiological barriers.
- These barriers include the liver canalicular membrane, kidney proximal tubules, intestinal enterocytes, and placental syncytiotrophoblast.
Purpose of the Study:
- To summarize the expression, localization, and transport functions of ABCC2/Abcc2.
- To highlight the clinical significance of ABCC2/Abcc2 mutations, particularly in Dubin-Johnson syndrome.
Main Methods:
- Literature review and analysis of existing data on ABCC2/Abcc2 function.
- Examination of the substrate specificity and kinetic properties of the transporter.
Main Results:
- ABCC2/Abcc2 transports a wide range of amphiphilic anions, including endogenous compounds, drugs, and toxins.
- The transporter shows a preference for phase II conjugates.
- Mutations in ABCC2 lead to Dubin-Johnson syndrome, characterized by hyperbilirubinemia.
Conclusions:
- ABCC2/Abcc2 plays a vital role in the transport of various substances across physiological barriers.
- Its complex transport kinetics and multiple binding sites contribute to its diverse functions.
- Understanding ABCC2/Abcc2 is critical for comprehending drug disposition and certain genetic disorders.
Related Concept Videos
01:31ABC Transporters: Exporter
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
01:27ABC Transporters: Importer
ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
01:06Carrier-Mediated Transport
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
01:16Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
01:31Membrane Transporters
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
01:42The ADP/ATP Carrier Protein
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...