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Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes

S Lalande1, P L Hofman, J C Baldi

  • 1Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand. lalande.sophie@mayo.edu

Acta Physiologica (Oxford, England)
|January 20, 2010
PubMed

Insights

Men with type 2 diabetes exhibit reduced stroke volume and end-diastolic volume, linked to lower blood volume and higher heart rate, impacting cardiac function.

Area of Science:

  • Cardiology
  • Diabetology
  • Physiology

Background:

  • Type 2 diabetes is frequently associated with impaired left ventricular (LV) diastolic function.
  • The specific causes, whether altered LV relaxation or preload changes, remain unclear.

Purpose of the Study:

  • To investigate the impact of LV function and loading conditions on stroke volume in men with type 2 diabetes.

Main Methods:

  • Cardiac MRI was used in men with type 2 diabetes and matched non-diabetic controls.
  • Total blood volume was measured using the Evans blue dye dilution technique.

Main Results:

  • Men with type 2 diabetes had lower end-diastolic volume (EDV), stroke volume, and E/A ratio.
  • Higher heart rate and lower total blood volume were observed in diabetic men, correlating with lower EDV.

Conclusions:

  • Type 2 diabetes is associated with altered cardiac cycles, reduced EDV, and stroke volume.
  • Reduced LV preload, indicated by lower total blood volume and higher heart rate, influences diastolic filling and stroke volume in diabetic men.
Abstract

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