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Polymorphism (ALA16VAL) correlates with regional lymph node status in breast cancer
Claudia Giuliano Bica1, Leonardo Leiria de Moura da Silva, Nadima Vieira Toscani
1Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências Médicas de Porto Alegre, Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil.
Cancer Genetics and Cytogenetics
|January 20, 2010
Summary
The manganese-dependent superoxide dismutase (MnSOD) VV genotype may indicate a higher metastatic potential in breast cancer patients. This finding suggests MnSOD imbalance contributes to cancer development and spread.
Area of Science:
- Genetics
- Oncology
- Biochemistry
Background:
- Previous studies suggest a link between the AA genotype of the manganese-dependent superoxide dismutase (MnSOD) gene and breast cancer risk.
- The role of MnSOD genotypes in breast cancer progression, particularly lymph node metastasis, requires further investigation.
Purpose of the Study:
- To investigate the association between Ala16Val MnSOD gene polymorphisms and lymph node status in breast cancer.
- To explore potential correlations between MnSOD genotypes and immunohistochemical markers (p53, Ki-67, ER/PR) in breast cancer patients.
Main Methods:
- Genotyping of MnSOD polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 281 women (93 cases, 188 controls).
- Analysis of DNA extracted from tumor tissue or peripheral blood leukocytes.
- Immunohistochemical analysis of p53, Ki-67, and hormone receptors in relation to MnSOD genotypes.
Main Results:
- The VV genotype frequency was significantly higher in the lymph node-positive (LN+) breast cancer group compared to controls and the lymph node-negative (LN-) group (P=0.02).
- LN+ breast cancer patients with the VV genotype showed a higher incidence of positive Ki-67 marker.
- LN+ breast cancer patients with the VV genotype exhibited a higher incidence of negative p53 marker.
Conclusions:
- While the AA genotype is linked to increased breast cancer risk, the VV genotype may be associated with enhanced metastatic potential.
- MnSOD imbalance appears to be a contributing factor in breast cancer carcinogenesis and progression.
