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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Study on TP53 codon 72 polymorphisms with oral carcinoma susceptibility.

Xian-Lu Zhuo¹, Qi Li, Yan Zhou

¹Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.

Archives of Medical Research

|January 20, 2010

Summary

TP53 codon 72 polymorphisms are not linked to oral cancer risk. This meta-analysis of nine studies found no significant association between TP53 genotypes and oral carcinoma susceptibility in diverse populations.

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

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Published on: February 28, 2019

Area of Science:

Genetics and Cancer Epidemiology
Molecular Oncology
Human Genetics

Background:

Previous studies suggest TP53 codon 72 polymorphisms may influence cancer risk.
Inconclusive evidence exists regarding the association between TP53 codon 72 polymorphisms and oral carcinoma susceptibility.

Purpose of the Study:

To precisely estimate the relationship between TP53 codon 72 polymorphisms and oral carcinoma risk.
To synthesize existing evidence through meta-analysis.

Main Methods:

Systematic literature search of relevant databases until May 2009.
Inclusion criteria applied to select nine studies comprising 1990 cases and 2074 controls.
Meta-analysis performed to assess the association between TP53 codon 72 genotypes and oral cancer risk.

Main Results:

No significant difference in oral cancer risk was observed for Arg/Arg genotype versus Pro/Pro genotype (OR: 0.96).
No significant risk was found for Arg/Arg genotype compared to combined Pro genotypes (OR: 0.98).
Combined Arg genotypes showed no increased or decreased susceptibility compared to Pro/Pro (OR: 1.00), irrespective of race, smoking status, or HPV infection.

Conclusions:

Current evidence does not support TP53 codon 72 polymorphisms as a risk factor for oral carcinoma.
The investigated TP53 genotypes do not appear to influence oral cancer susceptibility.