Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Stroke: Introduction and Types

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Locked-in syndrome.

Handbook of clinical neurology·2026

Same author

Biomarkers for advancing diagnosis and prognosis in stroke.

The Lancet. Neurology·2026

Same author

Perilesional white matter gradients reveal microstructural differences in cerebral amyloid angiopathy versus Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

A Standardized Anatomical Classification of Intracranial Hemorrhage.

Cerebrovascular diseases (Basel, Switzerland)·2026

Same author

Transient ischemic attack in the twenty first century: is it still a useful construct?

Frontiers in stroke·2026

Same author

Chronic Subdural Hematoma Treatment with Embolization Versus Surgery Study (CHESS): Trial Rationale and Protocol.

International journal of cerebrovascular disease and stroke·2025

Same journal

Resolution of expression of concern-Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional study.

The Lancet. Neurology·2026

Same journal

UCL Queen Square Institute of Neurology: 75 years of innovation.

The Lancet. Neurology·2026

Same journal

Correction to Lancet Neurol 2026; 25: 631.

The Lancet. Neurology·2026

Same journal

Epstein-Barr virus and multiple sclerosis: from associations to mechanisms to potential therapies.

The Lancet. Neurology·2026

Same journal

Correction to Lancet Neurol 2025; 24: 740-52.

The Lancet. Neurology·2026

Same journal

Correction to Lancet Neurol 2026; 25: 357-67.

The Lancet. Neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Medical complications after stroke.

Sandeep Kumar¹, Magdy H Selim, Louis R Caplan

¹Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. skumar@bidmc.harvard.edu

The Lancet. Neurology

|January 20, 2010

Summary

This summary is machine-generated.

Stroke survivors face numerous medical complications that hinder recovery. Effective prevention and treatment strategies for these common issues, such as cardiac problems and pneumonia, require further systematic investigation.

More Related Videos

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

Published on: December 29, 2023

Related Experiment Videos

Last Updated: Jun 17, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

Published on: December 29, 2023

Area of Science:

Neurology
Internal Medicine
Critical Care Medicine

Background:

Stroke patients frequently experience comorbidities like hypertension and diabetes, increasing risks during recovery.
Medical complications can stem directly from brain injury, disabilities, immobility, or treatments.
These complications significantly impact patient outcomes and impede neurological recovery.

Purpose of the Study:

To investigate the impact of medical complications on stroke recovery.
To identify common post-stroke complications requiring intervention.
To highlight the need for improved prevention and treatment strategies.

Main Methods:

Review of existing literature on post-stroke complications.
Analysis of common medical issues affecting stroke patients.
Identification of gaps in current management guidelines.

Main Results:

Common complications include cardiac issues, pneumonias, venous thromboembolism, fever, pain, dysphagia, incontinence, and depression.
These events substantially affect stroke outcomes and neurological recovery.
Limited data currently guide the management of these frequent complications.

Conclusions:

Medical complications are a significant concern for stroke patients, affecting recovery and outcomes.
Specific interventions are often required for common post-stroke complications.
Further systematic research is essential to enhance the management of these events and improve patient recovery.