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Updated: Jun 17, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
Published on: January 5, 2018
Disulfiram, an option for the treatment of pathological gambling?
Jochen Mutschler1, Mira Bühler, Martin Grosshans
1Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany. jochen.mutschler@puk.zh.ch
Aim:
Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine beta-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling.
Method:
We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D.
Results:
During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months.
Conclusions:
Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gambling.
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