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Related Concept Videos

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...

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Related Experiment Video

Updated: Jun 17, 2026

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
07:58

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry

Published on: April 3, 2019

Elucidating structure-function relationships from molecule-to-cell-to-tissue: from research modalities to clinical

L W Dobrucki1, B J Marsh, L Kalinowski

  • 1Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06513, USA. wawrzyniec.dobrucki@yale.edu

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|January 20, 2010
PubMed
Summary

Advanced imaging techniques, including ultramicrosensors and electron tomography, offer revolutionary potential for diagnosing and treating diseases. Integrated imaging approaches promise personalized medicine and improved healthcare outcomes.

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Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
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Last Updated: Jun 17, 2026

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
07:58

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Published on: April 3, 2019

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
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Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy

Published on: September 8, 2009

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Cellular Biology

Background:

  • Imaging is a 20th-century engineering achievement with vast potential in medicine.
  • Integrated imaging can revolutionize disease diagnosis and treatment.
  • Current healthcare faces significant social and economic costs from disease management.

Purpose of the Study:

  • To provide an update on state-of-the-art imaging modalities.
  • To highlight imaging's role in integrated approaches for improved clinical outcomes.
  • To discuss specific advanced imaging techniques and their applications.

Main Methods:

  • Review of advanced imaging modalities.
  • Focus on ultramicrosensors for reactive oxygen/nitrogen species detection.
  • Application of electron tomography for 3D cellular visualization.
  • Molecular imaging strategies for assessing angiogenesis.

Main Results:

  • Ultramicrosensors enable single-cell detection of reactive oxygen/nitrogen species.
  • Electron tomography provides detailed 3D cellular organization.
  • Molecular imaging assesses angiogenesis using targeted tracers.
  • Integrated imaging enhances diagnosis, risk stratification, and cell therapies.

Conclusions:

  • Integrated imaging approaches hold extraordinary potential for disease management.
  • Advanced imaging techniques can lead to individualized disease prevention programs.
  • These modalities promise more successful and efficient healthcare delivery.