Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disseminated intravascular coagulation, clarity of existing terminology… or more confusion?

Journal of thrombosis and haemostasis : JTH·2026
Same author

Disseminated intravascular coagulation resolution as a surrogate outcome for mortality in sepsis-associated disseminated intravascular coagulation.

Thrombosis research·2025
Same author

Erratum: Utility of Sepsis-induced Coagulopathy among Disseminated Intravascular Coagulation Diagnostic Criteria: A Multicenter Retrospective Validation Study.

Thrombosis and haemostasis·2025
Same author

Correction: Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4-trauma, burn, obstetrics, acute pancreatitis/liver failure, and others.

International journal of hematology·2025
Same author

Carbapenem Usage in the Initial Antibiotic Therapy of Sepsis in Japanese Intensive Care Units.

Cureus·2025
Same author

Utility of Sepsis-induced Coagulopathy Among Disseminated Intravascular Coagulation Diagnostic Criteria: A Multicenter Retrospective Validation Study.

Thrombosis and haemostasis·2025

Related Experiment Video

Updated: Jun 17, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Microvascular thrombosis and multiple organ dysfunction syndrome.

Satoshi Gando1

  • 1Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan. gando@med.hokudai.ac.jp

Critical Care Medicine
|January 20, 2010
PubMed
Summary

Disseminated intravascular coagulation causes microvascular thrombosis, leading to multiple organ dysfunction syndrome. The interaction between this condition and systemic inflammatory response syndrome worsens outcomes in critically ill patients.

More Related Videos

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Related Experiment Videos

Last Updated: Jun 17, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

  • Critical Care Medicine
  • Pathophysiology
  • Hematology

Background:

  • Disseminated intravascular coagulation (DIC) is a critical condition characterized by microvascular thrombosis.
  • Systemic inflammatory response syndrome (SIRS) frequently co-occurs in critically ill patients.
  • The interplay between DIC and SIRS is implicated in the pathogenesis of multiple organ dysfunction syndrome (MODS).

Purpose of the Study:

  • To review the role of DIC-induced microvascular thrombosis in MODS.
  • To examine the interaction between DIC and SIRS in critically ill patients.
  • To elucidate the pathogenic mechanisms of MODS.

Main Methods:

  • Literature review of published clinical and experimental studies.
  • Analysis of histologic evidence from clinical, experimental, and autopsy findings.
  • Examination of molecular pathways involving cytokines, neutrophils, endothelial cells, and protease-activated receptors.

Main Results:

  • Histologic evidence confirms microvascular thrombosis and tissue injury in DIC.
  • Proinflammatory cytokines and protease-activated receptors promote fibrin deposition in organs.
  • DIC and SIRS synergistically contribute to MODS development and poor prognosis.

Conclusions:

  • DIC-induced microvascular thrombosis is a key factor in MODS pathogenesis.
  • The interaction between DIC and SIRS significantly impacts critical illness outcomes.
  • Understanding these interactions provides insight into MODS mechanisms.