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Related Experiment Video

Updated: Jun 17, 2026

Spinal Cord Electrophysiology

Spinal Cord Electrophysiology

Published on: January 18, 2010

Spinal cord electrophysiology.

Allyn Meyer¹, Benjamin W Gallarda, Samuel Pfaff

¹The Salk Institute for Biological Studies, Howard Hughes Medical Institute and Gene Expression Laboratory.

Journal of Visualized Experiments : Jove

|January 20, 2010

Summary

This summary is machine-generated.

This study details how to dissect neonatal mouse spinal cords for studying neural circuits and movement. It explains preparing artificial cerebrospinal fluid and recording nerve root signals to analyze central pattern generating circuitry.

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The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation

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Published on: September 8, 2023

Area of Science:

Neuroscience
Developmental Biology

Background:

The neonatal mouse spinal cord is a valuable model for understanding neural circuit development and locomotion.
Studying neural control of movement requires precise preparation techniques.

Purpose of the Study:

To provide a detailed protocol for spinal cord dissection in neonatal mice.
To outline the preparation of artificial cerebrospinal fluid for electrophysiological recordings.
To demonstrate the recording of electrophysiologic signals from the central pattern generating circuitry.

Main Methods:

Neonatal mouse spinal cord dissection.
Preparation of artificial cerebrospinal fluid (ACSF).
Attachment of ventral nerve roots to a recording electrode for signal acquisition.

Main Results:

Successful dissection and preparation of the neonatal mouse spinal cord for electrophysiological analysis.
Demonstration of recording electrophysiologic signals from the lumbar spinal cord.
Identification of signals related to central pattern generating circuitry.

Conclusions:

This protocol enables the study of neural circuitries underlying locomotor movement in neonatal mice.
The method allows for the investigation of electrophysiologic activity within the central pattern generating circuitry.
Provides a foundation for further research into spinal cord development and function.