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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Management of anaphylaxis in primary care: Canadian expert consensus recommendations.

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Related Experiment Video

Updated: Jun 17, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Allergies in children.

Z Chad1

  • 1Chair, Canadian Allergy, Asthma and Immunology Foundation, Ottawa, Ontario.

Paediatrics & Child Health
|January 20, 2010
PubMed
Summary

Childhood allergic diseases are rising, affecting 35% of children. Early dietary and environmental controls are key to preventing allergen sensitization and managing symptoms in high-risk children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Genetics

Background:

  • Childhood allergic diseases have significantly increased, now impacting up to 35% of the pediatric population.
  • These conditions represent a major cause of childhood morbidity.
  • Both genetic predisposition and environmental exposures play critical roles in allergen sensitization.

Purpose of the Study:

  • To summarize current understanding of allergic disease development in children.
  • To highlight the importance of environmental and dietary factors in allergen sensitization.
  • To outline current best practices for managing children at high risk for allergies.

Main Methods:

  • Review of current scientific literature on pediatric allergies.
  • Analysis of genetic and environmental factors influencing immune system development.
Keywords:
Allergic diseasesAllergiesEnvironmental factors

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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

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Related Experiment Videos

Last Updated: Jun 17, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

  • Synthesis of evidence-based strategies for allergy prevention and management.

    • Main Results:

    • Allergen sensitization is determined by the interplay of genetic predisposition and exposure to environmental allergens, irritants, and infections.
    • Understanding the roles of genetic and environmental factors in the immature immune system is crucial for developing preventive strategies.
    • Early implementation of dietary and environmental controls can decrease sensitization in high-risk children.

    Conclusions:

    • Current best practice for high-risk children involves early dietary and environmental control measures to reduce allergen sensitization.
    • Prompt recognition and appropriate treatment of evolving allergic signs and symptoms are essential.
    • Further research into genetic and environmental interactions will inform more enduring preventive efforts.