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[Global pertussis epidemiology and immunization strategies]
1Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhongguo Yi Miao He Mian Yi
|January 21, 2010
Summary
Pertussis (whooping cough) is a growing global health concern, with rising cases in vaccinated adolescents and adults. This review examines pertussis epidemiology shifts and discusses vaccination strategies to combat resurgence.
Area of Science:
- Public Health
- Epidemiology
- Immunology
Background:
- Pertussis (whooping cough) persists as a global public health issue, despite high universal vaccination coverage.
- Disease epidemiology has shifted, with notable increases in pertussis incidence among adolescents and adults.
- Reported cases likely underestimate the true burden of pertussis due to an extensive asymptomatic or mild case reservoir.
Purpose of the Study:
- To review the changing epidemiology of pertussis.
- To identify the underlying causes contributing to the resurgence of pertussis.
- To inform pertussis vaccination strategy reconsideration by comparing international immunization schedules.
Main Methods:
- Literature review of pertussis epidemiology.
- Analysis of disease trends in vaccinated populations.
- Comparative assessment of national pertussis immunization schedules.
Main Results:
- Significant increase in pertussis cases observed in adolescents and adults.
- Vaccination schedules vary internationally, potentially impacting disease control.
- The full extent of pertussis circulation is likely greater than reported case numbers indicate.
Conclusions:
- Pertussis resurgence necessitates a re-evaluation of current vaccination strategies.
- Adolescent and adult booster programs are being implemented in response to epidemiological changes.
- International comparisons of immunization schedules may offer insights for optimizing national pertussis control efforts.
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