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Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants

Louise Kirby1, Sonya Agarwal, James F Graham

  • 1Neuropathogenesis Division, The Roslin Institute and Royal (Dick) School of Veterinary Studies, The Alexander Robertson Building, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.

Biochemistry
|January 21, 2010
PubMed
Summary

Amino acid changes in prion protein (PrP) affect transmissible spongiform encephalopathies (TSEs) susceptibility. Altered protein stability and structure influence misfolding, impacting disease resistance.

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