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[Pneumothorax in cystic fibrosis].

A Aebersold1, U B Schaad

  • 1Medizinische Universitäts-Kinderklinik Bern.

Schweizerische Medizinische Wochenschrift
|February 9, 1991
PubMed
Summary

Increased pneumothorax (PT) in cystic fibrosis (CF) patients necessitates effective treatment. Quinacrine sclerosis offers a successful, less invasive option for preventing recurrent PT after initial chest tube drainage.

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Drug therapy in children: still more art than science.

Current opinion in infectious diseases·2002

Area of Science:

  • Pulmonology
  • Pediatric Medicine
  • Thoracic Surgery

Context:

  • Rising life expectancy in cystic fibrosis (CF) patients leads to more advanced lung disease.
  • Pneumothorax (PT) is an increasingly common complication in advanced CF stages.
  • This study retrospectively analyzed PT events in pediatric CF patients over 15 years.

Purpose:

  • To evaluate the long-term efficacy of different therapeutic modalities for pneumothorax in pediatric cystic fibrosis patients.
  • To compare complication rates and hospital stays between treatment options.
  • To identify optimal prophylactic strategies for recurrent pneumothorax in this population.

Summary:

  • 23 pediatric CF patients experienced 51 PT events, including 18 tension pneumothoraces, with a mean age of 15.6 years at first episode.
  • Therapeutic success rates varied: observation (24%), pleural suction drainage (9%), quinacrine sclerosis (75%), and open thoracotomy (90%).
  • Quinacrine sclerosis demonstrated comparable efficacy to thoracotomy with fewer complications and shorter hospitalizations.

Impact:

  • Quinacrine sclerosis is recommended as a primary prophylactic treatment for recurrent PT in CF patients post-chest tube evacuation.
  • This approach may improve patient outcomes and reduce the burden of recurrent pneumothorax.
  • The study found no CF disease deterioration or PT-related deaths, suggesting manageable risks with appropriate treatment.

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