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Updated: Jun 16, 2026

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
Published on: June 16, 2020
The beat goes on: three decades of stunning advances in cardiology
1The Physician and Sportsmedicine, Minneapolis, MN, 55435, USA.
Insights
Jim Fixx
Area of Science:
- Cardiology
- Exercise Physiology
- Public Health
Background:
- The 1970s fitness boom, popularized by Jim Fixx, raised questions about exercise safety.
- Fixx's death from a heart attack at 52, with severe coronary artery narrowing, spurred interest in exercise risks.
- Cardiovascular disease (CVD) remains a leading cause of death despite declining mortality rates.
Purpose of the Study:
- To explore the historical context of exercise enthusiasm and cardiovascular disease research.
- To examine the impact of public figures' health events on scientific inquiry.
- To highlight the ongoing significance of cardiovascular disease as a public health concern.
Main Methods:
- Historical review of the fitness movement and related scientific literature.
- Analysis of autopsy findings and their influence on research directions.
- Examination of trends in cardiovascular disease mortality.
Main Results:
- Jim Fixx's death and autopsy findings significantly influenced research into exercise risks and cardiovascular disease origins.
- Public interest in fitness grew alongside scientific investigation into heart health.
- While CVD death rates have decreased, cardiovascular disease remains a primary health challenge.
Conclusions:
- Public health initiatives and scientific research are interconnected.
- Understanding the origins of cardiovascular disease is crucial for public health.
- Continued research is necessary to address the ongoing threat of cardiovascular disease.
Abstract:
When Jim Fixx's The Complete Book of Running became a best-seller, it helped fuel the physical fitness enthusiasm that swept the United States in the mid-to-late 1970s. When he died of a heart attack while running at age 52 a few years later, his death created a stir. An autopsy revealed that his coronary arteries were narrowed by 80% to 99%, and provoked an interest in the risks of exercise in younger people that paralleled growing research into the origins of cardiovascular disease (CVD). Despite the steady decline in deaths from cardiovascular causes, CVD remains the leading cause of death in the United States today.
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