Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Systematic review of self-expanding stents in the management of benign colorectal obstruction.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Hip Fracture Service-an interdisciplinary model of care.

Journal of the American Geriatrics Society·2002
Same author

Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.

The Journal of clinical endocrinology and metabolism·2001
Same author

Aspiration pneumonia.

The New England journal of medicine·2001
Same author

Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men.

American journal of physiology. Endocrinology and metabolism·2001
Same journal

Injury surveillance during the 2024 under 20s Men's European Field Lacrosse Championships.

The Physician and sportsmedicine·2026
Same journal

Understanding health insurance and the delay in care for partial meniscectomies: a comparison between public and private coverage.

The Physician and sportsmedicine·2026
Same journal

Injury incidence and risk factors in youth American football versus soccer: a national emergency department analysis.

The Physician and sportsmedicine·2026
Same journal

Links between concussion history, hypertension, and hypertension contributing factors among adolescent football athletes.

The Physician and sportsmedicine·2026
Same journal

Core muscle endurance and balance as predictors of lateral ankle sprain in adolescent team-sport athletes: a prospective cohort study.

The Physician and sportsmedicine·2026
Same journal

Impact of Achilles tendon rupture on performance and career outcomes in NFL players: a matched cohort study.

The Physician and sportsmedicine·2026
See all related articles

Related Experiment Videos

Fitness for reducing osteoporosis.

C Christmas1

  • 1Johns Hopkins Geriatric Center, Baltimore, MD, 21224, USA. cchristm@jhmi.edu.

The Physician and Sportsmedicine
|January 21, 2010
PubMed
Summary
This summary is machine-generated.

Osteoporosis and fractures significantly increase with age, impacting millions annually and leading to substantial healthcare costs and poor patient outcomes. This condition necessitates urgent attention due to its widespread prevalence and severe health consequences.

Related Experiment Videos

Area of Science:

  • Gerontology
  • Orthopedics
  • Public Health

Background:

  • Osteoporosis prevalence and incidence rise significantly with age in both sexes.
  • One in five women over 50 have osteoporosis, leading to millions of fractures annually in the US.
  • Osteoporotic fractures impose a considerable burden on healthcare systems.

Purpose of the Study:

  • To highlight the increasing incidence and prevalence of osteoporosis and fractures.
  • To underscore the significant healthcare costs associated with osteoporotic fractures.
  • To emphasize the poor functional recovery and increased mortality following hip fractures.

Main Methods:

  • Literature review and data synthesis on osteoporosis and fracture statistics.
  • Analysis of age-related trends in osteoporosis and fracture incidence.
  • Examination of post-fracture outcomes, including functional recovery and mortality rates.

Main Results:

  • Fracture incidence and prevalence increase substantially with age.
  • Nearly 1.5 million osteoporotic fractures occur yearly in the US, incurring high healthcare costs.
  • Less than one-third of hip fracture patients regain independence, and mortality is higher than in unaffected peers.

Conclusions:

  • Osteoporosis and associated fractures represent a major public health challenge, particularly for aging populations.
  • The economic and human cost of osteoporotic fractures is substantial, demanding effective prevention and management strategies.
  • Improved patient outcomes and reduced mortality post-fracture are critical goals for healthcare interventions.