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Updated: Jun 16, 2026
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Controlling blood lipids part 2: when and how to use medication
1Cooper Clinic, Dallas, TX, 75230-2223, USA.
The Physician and Sportsmedicine
|January 21, 2010
Summary
Statins are the most effective and safest drug for abnormal blood lipids. Guidelines exist for treating high cholesterol, with additional tests aiding treatment decisions for specific patients.
Area of Science:
- Cardiology
- Pharmacology
- Preventive Medicine
Background:
- Abnormal blood lipid levels increase cardiovascular disease risk.
- Current drug treatments include bile acid sequestrants, fibric acid derivatives, statins, and niacin.
- Hormone replacement therapy is beneficial for postmenopausal women.
Purpose of the Study:
- To review drug treatments for abnormal blood lipids.
- To provide guidance on cholesterol management.
- To discuss the role of advanced lipid measurements in treatment decisions.
Main Methods:
- Literature review of lipid-lowering drugs.
- Analysis of National Cholesterol Education Program guidelines.
- Discussion of emerging lipid biomarkers.
Main Results:
- Statins offer the best safety and efficacy profile for lipid management.
- Established guidelines exist for low-density lipoprotein cholesterol (LDL-C) treatment thresholds.
- Recommendations are provided for high-density lipoprotein cholesterol (HDL-C) treatment levels.
Conclusions:
- Statins are a primary pharmacologic option for dyslipidemia.
- Adherence to NCEP guidelines is crucial for effective cholesterol management.
- Novel lipid markers like small dense LDL-C and lipoprotein(a) aid in personalized treatment strategies.
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