Related Experiment Video
Updated: Jun 16, 2026

10:49
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Xenaderm: an essential wound care therapy
1Department of Urology at the Hospital of the University of Pennsylvania, Philadelphia, USA.
Advances in Skin & Wound Care
|January 21, 2010
Summary
Xenaderm significantly accelerates wound healing, demonstrating efficacy in clinical trials. This topical therapy is safe, cost-effective, and recommended for managing partial-thickness wounds, improving patient outcomes.
Area of Science:
- Wound care management
- Dermatology
- Regenerative medicine
Background:
- Iatrogenic skin damage presents a significant challenge in healthcare.
- Effective wound management is crucial for patient recovery and quality of life.
Purpose of the Study:
- To evaluate the clinical efficacy, indications, and application of Xenaderm in wound care.
- To assess Xenaderm's role in managing partial-thickness wounds.
Main Methods:
- Systematic review of healthcare literature from Medline and Ovid databases.
- Inclusion of clinical trials and case studies published after 2003.
- Focus on studies evaluating wound healing duration with Xenaderm.
Main Results:
- Xenaderm demonstrated efficacy, healing wounds twice as fast as saline.
- The therapy is safe and cost-effective.
- Xenaderm is suitable for most partial-thickness wounds.
Conclusions:
- Xenaderm is an essential topical therapy for facilitating wound healing.
- It reduces hospital financial costs and improves patient quality of life.
- Xenaderm is recommended for inclusion in wound care algorithms.
Related Concept Videos
Phases of Wound Repair
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

