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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
What is the Immune System?01:38

What is the Immune System?

Overview
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

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Related Experiment Video

Updated: Jun 16, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

What is hot in autoimmunity.

Carlo Selmi1

  • 1Department of Internal Medicine, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy. carlo.selmi@unimi.it

Acta Reumatologica Portuguesa
|January 21, 2010
PubMed
Summary
This summary is machine-generated.

Recent immunology research reveals exponential growth in understanding autoimmune diseases. Key developments in T helper 17 cells, regulatory T cells, and innate immunity offer promising new treatments.

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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

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Related Experiment Videos

Last Updated: Jun 16, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Area of Science:

  • Immunology
  • Autoimmune Diseases

Background:

  • The study reviews recent advancements in understanding the pathogenesis, susceptibility, and treatment of autoimmune diseases.
  • The discovery pace in immunology, particularly autoimmunity, has been exponential, necessitating a timely discussion.

Purpose of the Study:

  • To review major issues in basic, clinical, and translational autoimmunity research from leading journals over the past 18 months.
  • To highlight the growing similarities in pathogenesis and mechanisms across different autoimmune conditions.

Main Methods:

  • Comprehensive literature review of publications in leading scientific journals.
  • Focus on key areas including T helper 17 cell paradigm, regulatory T cells, and the innate immune system.

Main Results:

  • Significant progress in understanding the T helper 17 paradigm and the role of T regulatory cells.
  • Increased focus on the innate immune system's role in autoimmunity.
  • Emerging translational works show promising data for clinical application.

Conclusions:

  • Autoimmunity is increasingly viewed as a unified scenario with more similarities than differences in pathogenesis.
  • The review aims to guide basic scientists and clinicians toward new research directions.
  • Recent findings underscore the potential for novel therapeutic strategies impacting patient care.