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The ACE I/D polymorphism in elite Greek track and field athletes
I D Papadimitriou1, C Papadopoulos, A Kouvatsi
1Laboratory of Sports Biomechanics, Aristotle University, Serres, Greece.
The Journal of Sports Medicine and Physical Fitness
|January 21, 2010
Summary
Genetic analysis of elite Greek athletes revealed no significant differences in Angiotensin-Converting Enzyme (ACE) gene variants compared to controls. However, a trend suggests the ACE DD genotype may influence sprint performance.
Area of Science:
- Sports Science
- Human Genetics
- Molecular Biology
Background:
- The Angiotensin-Converting Enzyme (ACE) gene is implicated in athletic performance.
- Genetic variations, specifically the I/D polymorphism, are studied for their potential role in elite athletes.
- Understanding these genetic factors can offer insights into athletic specialization.
Purpose of the Study:
- To investigate genetic variations in the ACE gene among elite Greek track and field athletes.
- To compare the I/D polymorphism frequencies between athletes and a control population.
- To explore potential associations between ACE genotypes and athletic performance.
Main Methods:
- DNA analysis of 101 elite Greek track and field athletes and 181 controls.
- Polymerase Chain Reaction (PCR) used for DNA amplification.
- Agarose gel electrophoresis and specific PCR primers for accurate genotype determination.
Main Results:
- No statistically significant differences in ACE genotype and allele frequencies were observed between elite athletes and the control group.
- A trend indicated a higher frequency of the ACE DD genotype in sprinters (55.88%) compared to the control group (31.49%).
Conclusions:
- The study found weak evidence suggesting a potential influence of the ACE DD genotype on sprint performance in Greek athletes.
- Further research is warranted to confirm the association between ACE gene variants and athletic specialization.
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