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[Pulmonary edema induced by hydrochlorothiazide/amiloride (Moduretic)]
J E Nielsen-Kudsk1, A S Knudsen, P V Sørensen
1Medicinsk afdeling, Silkeborg Centralsygehus.
Ugeskrift for Laeger
|March 11, 1991
Summary
Hydrochlorothiazide-amiloride can cause acute pulmonary edema, a rare but serious side effect. This noncardiogenic reaction, possibly due to increased vascular permeability, requires clinical attention.
Area of Science:
- Pharmacology
- Pulmonology
- Toxicology
Background:
- Hydrochlorothiazide-amiloride is a commonly prescribed diuretic.
- Pulmonary edema is a potential adverse effect of this medication.
Observation:
- A 44-year-old woman experienced acute pulmonary edema 30 minutes after ingesting hydrochlorothiazide-amiloride.
- Eighteen prior cases of similar reactions were identified.
Findings:
- The pulmonary edema appears to be noncardiogenic in origin.
- Increased pulmonary vascular permeability is a suspected mechanism, though immunological causes have not been confirmed.
- The pathophysiology remains uncertain.
Implications:
- This rare side effect can mimic left ventricular failure, complicating diagnosis in cardiac patients.
- Clinicians should be aware of this severe adverse reaction to hydrochlorothiazide-amiloride.