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Related Experiment Video

Updated: Jun 16, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Murine Colitis modeling using Dextran Sulfate Sodium (DSS).

Caitlyn G Whittem1, Amanda D Williams, Christopher S Williams

  • 1Department of Cancer Biology, Vanderbilt University, USA.

Journal of Visualized Experiments : Jove
|January 21, 2010
PubMed
Summary
This summary is machine-generated.

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Dextran Sodium Sulfate (DSS) in drinking water induces acute colitis in mice, causing weight loss and bloody stools. This model is crucial for studying inflammatory bowel disease mechanisms and potential treatments.

Area of Science:

  • Gastroenterology
  • Immunology
  • Toxicology

Background:

  • Colitis encompasses various conditions including Ulcerative Colitis and Crohn's Colitis.
  • Inflammatory Bowel Disease (IBD) involves complex interactions between genetics, environment, and epithelial barrier function.
  • Animal models are vital for understanding IBD and colitis.

Purpose of the Study:

  • To describe the Dextran Sodium Sulfate (DSS) mouse model for inducing acute colitis.
  • To detail the methodology for assessing colitis severity and colonic tissue.

Main Methods:

  • Mice were administered 3% DSS in drinking water for four days to induce acute colitis.
  • Clinical signs such as weight loss, bloody stools, and diarrhea were monitored.
  • Colons were analyzed macroscopically and microscopically after necropsy.

More Related Videos

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Related Experiment Videos

Last Updated: Jun 16, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Main Results:

  • DSS administration led to significant weight loss, bloody stools, and diarrhea in mice.
  • Macroscopic and microscopic examination revealed colonic damage and inflammation.

Conclusions:

  • The DSS model effectively replicates key features of acute colitis in mice.
  • This model facilitates research into the pathogenesis and therapeutic strategies for inflammatory bowel diseases.