Related Experiment Video
Updated: Jun 16, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Proline-rich hypothalamic polypeptide has opposite effects on the proliferation of human normal bone marrow stromal
R K Chailakhyan1, Yu V Gerasimov, M R Chailakhyan
1Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Gamaleya str., 18, 123098, Moscow, Russian Federation. info@riem.ru
Abstract:
In the present study we carried out experiments in vitro and in vivo and investigated the effect of proline-rich polypeptide (PRP) on the proliferation and effectiveness of colony formation of MMSCs in vitro. Various routes and doses of PRP administration to rats increased the number of MMSCs in bone marrow and spleen. Our research revealed opposite effects of PRP on the proliferation of bone marrow stromal cells obtained from normal humans and stromal cells isolated from a human giant-cell tumour.
Related Concept Videos
Abnormal Proliferation
Regulation of Hematopoietic Stem Cells
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Negative Regulator Molecules
Multipotency of Hematopoietic Stem Cells
Differentiation of Common Myeloid Progenitor Cells

