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Related Experiment Videos

Ranitidine-theophylline interaction--fact or fiction?

G W Hegman1, R P Gilbert

  • 1Bannock Regional Medical Center, Pharmacy Department, Pocatello, ID 83201.

DICP : the Annals of Pharmacotherapy
|January 1, 1991
PubMed
Summary

A patient experienced theophylline toxicity twice after taking ranitidine, indicating a potential drug interaction. This case highlights that ranitidine may increase theophylline levels in susceptible individuals, contradicting some controlled studies.

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Area of Science:

  • Clinical Pharmacology
  • Pharmacokinetics
  • Drug Interactions

Background:

  • Theophylline is a medication used for respiratory conditions.
  • Ranitidine is a medication commonly used to reduce stomach acid.
  • Potential drug interactions between ranitidine and theophylline have been debated.

Observation:

  • A 63-year-old woman experienced symptoms of theophylline toxicity on two occasions.
  • The toxicity coincided with the addition of ranitidine to her medication regimen.
  • Theophylline levels significantly increased when co-administered with ranitidine.

Findings:

  • Theophylline concentrations returned to normal upon discontinuation of ranitidine.
  • Rechallenging the patient with ranitidine led to a recurrence of theophylline toxicity.

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  • Case reports suggest a potential ranitidine-theophylline interaction in susceptible patients.

    • Implications:

    • This case report suggests a possible drug interaction between ranitidine and theophylline.
    • Healthcare providers should be aware of this potential interaction, especially in patients with theophylline.
    • Further research may be needed to identify patients at risk for this interaction.