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Corticosteroids for acute, severe asthma.

H W Kelly1, S Murphy

  • 1Pediatric Intensive Care Unit, Children's Hospital of New Mexico, Albuquerque 87131.

DICP : the Annals of Pharmacotherapy
|January 1, 1991
PubMed
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Corticosteroids effectively treat severe asthma, especially when given early to patients not responding to bronchodilators. Treatment duration varies, with shorter courses beneficial for outpatients.

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Corticosteroids have been a cornerstone in treating acute, severe asthma since the 1950s.
  • Numerous high-quality trials confirm their efficacy in both adults and children.

Purpose of the Study:

  • To review the established efficacy and define optimal use of corticosteroids in acute, severe asthma management.
  • To identify areas requiring further research, such as optimal duration and tapering strategies.

Main Methods:

  • Review of randomized, double-blind, placebo-controlled trials and other relevant studies on corticosteroid use in asthma.
  • Analysis of data regarding onset of response, dosage, administration, and treatment duration.

Main Results:

  • Corticosteroids are proven effective, with efficacy dependent on trial rigor.

Related Experiment Videos

  • Early administration in specific patient groups reduces hospitalizations.
  • Not all patients require immediate corticosteroid therapy; focus on those with incomplete bronchodilator response.

    • Conclusions:

    • Corticosteroids should be administered to patients with incomplete response to aggressive bronchodilator therapy.
    • Short courses (3-5 days) are effective for outpatients; 7-10 days for inpatients.
    • Individualized treatment duration based on patient response is recommended; further research on tapering and short-burst risks is needed.