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Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats.
Ana Seoane1, Chris J Tinsley, Malcolm W Brown
1Department of Anatomy, Medical Research Council, Centre for Synaptic Plasticity, University of Bristol, Bristol, UK.
Hippocampus
|January 21, 2010
Summary
Brain-derived neurotrophic factor (BDNF) is crucial for forming long-term recognition memory. Inhibiting BDNF in the perirhinal cortex specifically impaired memory consolidation after 24 hours.
Area of Science:
- Neuroscience
- Molecular Biology
- Cognitive Science
Background:
- Recognition memory is vital for daily life.
- The perirhinal cortex is key for familiarity discrimination.
- Brain-derived neurotrophic factor (BDNF) plays a role in neuronal plasticity.
Purpose of the Study:
- To investigate the role of BDNF in recognition memory.
- To determine if BDNF in the perirhinal cortex influences memory consolidation.
Main Methods:
- Infusion of antisense and sense oligodeoxynucleotides (ODNs) targeting BDNF into the perirhinal cortex.
- Testing recognition memory at short-term (20 min) and long-term (24 h) intervals.
Main Results:
- Antisense BDNF ODN significantly impaired long-term (24 h) recognition memory consolidation.
- Sense BDNF ODN and short-term (20 min) memory were not affected.
Conclusions:
- BDNF in the perirhinal cortex is essential for the consolidation of long-term recognition memory.
- Targeting BDNF may offer therapeutic potential for memory disorders.
