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Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats

Ana Seoane1, Chris J Tinsley, Malcolm W Brown

  • 1Department of Anatomy, Medical Research Council, Centre for Synaptic Plasticity, University of Bristol, Bristol, UK.

Hippocampus
|January 21, 2010
PubMed

The role of brain-derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long-term (24 h) but not shorter-term (20 min) recognition memory.

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