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Updated: Jun 16, 2026
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Functional role of KLF10 in multiple disease processes
Malayannan Subramaniam1, John R Hawse, Nalini M Rajamannan
1Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. subramaniam.malayannan@mayo.edu
Biofactors (Oxford, England)
|January 21, 2010
Summary
Kruppel-like factor 10 (KLF10) is a transcription factor involved in cell differentiation and apoptosis. It plays a key role in TGF-beta signaling, impacting cell proliferation and inflammation, and is a potential marker for diseases like breast cancer.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- KLF10, a zinc finger transcription factor, belongs to the Krüppel-like family.
- KLF10 is rapidly induced by various growth factors including TGFbeta, EGF, and BMP-2.
- It is implicated in diverse cellular processes and serves as a potential disease marker.
Purpose of the Study:
- To summarize the known functions and signaling pathways of KLF10.
- To highlight KLF10's role in cell differentiation, proliferation, and apoptosis.
- To underscore KLF10's significance in human diseases.
Main Methods:
- Literature review of publications on KLF10.
- Analysis of KLF10's induction by signaling pathways.
- Examination of KLF10's DNA binding and transcriptional activity.
Main Results:
- KLF10 activates the TGFbeta-Smad signaling pathway by modulating Smad 7 and Smad 2 expression.
- KLF10 represses cell proliferation and inflammation while inducing apoptosis.
- Overexpression of KLF10 in osteoblasts and pancreatic cancer cells mimics TGFbeta actions.
Conclusions:
- KLF10 is a crucial mediator of TGFbeta signaling.
- KLF10 regulates key cellular processes including proliferation, inflammation, and apoptosis.
- KLF10 holds potential as a biomarker for diseases such as breast cancer, cardiac hypertrophy, and osteoporosis.
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