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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
Fungal skin infections associated with animal contact
1Texas Tech University Health Sciences Center School of Medicine, Lubbock.
Abstract:
Zoophilic dermatophytes are fungal organisms that primarily infect animals but occasionally infect humans. The most common of these are Microsporum canis and Trichophyton mentagrophytes. The clinical lesions of zoophilic fungal infections are more inflammatory than those caused by the typical anthropophilic fungi normally transmitted from person to person. To diagnose zoophilic fungal infections, a potassium hydroxide preparation of the skin scrapings may be examined microscopically or a culture may be obtained. Small lesions located anywhere except on the scalp may be treated with a topical antifungal agent. Oral griseofulvin is preferred for the treatment of scalp infections and extensive cutaneous infections.
Insights
Zoophilic dermatophytes, fungi primarily infecting animals, can cause inflammatory skin lesions in humans. Diagnosis involves microscopy or culture, with topical treatments for small lesions and oral griseofulvin for scalp or extensive infections.
Area of Science:
- Medical Mycology
- Dermatology
- Infectious Diseases
Background:
- Zoophilic dermatophytes are fungi that infect animals and can transmit to humans.
- Common species include Microsporum canis and Trichophyton mentagrophytes.
- Zoophilic infections often present with more inflammation than human-to-human transmitted fungal infections.
Purpose of the Study:
- To summarize the characteristics, diagnosis, and treatment of zoophilic dermatophyte infections in humans.
Main Methods:
- Review of existing literature on zoophilic dermatophyte infections.
- Description of diagnostic methods including potassium hydroxide (KOH) preparation and fungal culture.
- Outline of treatment strategies based on lesion location and extent.
Main Results:
- Zoophilic dermatophyte infections present with distinct, inflammatory skin lesions.
- Microscopic examination of skin scrapings (KOH prep) and fungal cultures are key diagnostic tools.
- Topical antifungal agents are effective for small, non-scalp lesions.
- Oral griseofulvin is the recommended treatment for scalp and extensive cutaneous infections.
Conclusions:
- Prompt diagnosis and appropriate treatment are crucial for managing zoophilic dermatophyte infections.
- Treatment choice depends on the location and severity of the fungal infection.
- Understanding the zoonotic transmission of dermatophytes aids in prevention and control.
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