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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Analgesic intolerance: pathogenesis, diagnosis and treatment]
1Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden.
Medizinische Monatsschrift Fur Pharmazeuten
|January 22, 2010
Summary
Analgesic intolerance, a sensitivity to nonsteroidal anti-inflammatory drugs (NSAR), causes various reactions. Early diagnosis and aspirin desensitization therapy can prevent severe symptoms and reduce surgery frequency.
Area of Science:
- Immunology
- Pharmacology
- Otolaryngology
Context:
- Analgesic intolerance affects 0.6-2.5% of the population, manifesting as cutaneous, respiratory, or gastrointestinal reactions.
- The "Samter triad" (asthma, NSAR sensitivity, nasal polyps) is a key clinical presentation.
- Symptoms include chronic rhinosinusitis, asthma, gastrointestinal ulcers, angioedema, and urticaria.
Purpose:
- To review nonsteroidal anti-inflammatory drug (NSAR) sensitivity and its management.
- To highlight the importance of early diagnosis of analgesic intolerance.
- To discuss diagnostic methods and causal therapy.
Summary:
- Analgesic intolerance involves reactions to NSAR, often presenting as the Samter triad.
- Diagnosis can be aided by challenge tests, but early identification is crucial.
- Aspirin desensitization therapy is the only causal treatment, effectively managing symptoms and reducing surgical interventions.
Impact:
- Early diagnosis and treatment of analgesic intolerance can prevent severe asthma attacks and other adverse reactions.
- Aspirin desensitization therapy significantly improves patient outcomes.
- Reduced frequency of endonasal revision surgery is a key benefit for patients with Samter triad.
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