Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Treatment of finger degloving injury with acellular dermal matrices: Functional and aesthetic results.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2019

Same author

Interleukin-17 and -22 synergy linking inflammation and EMT-dependent fibrosis in Sjögren's syndrome.

Clinical and experimental immunology·2019

Same author

Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity.

Carbohydrate polymers·2018

Same author

Heterogeneous vascular patterns in renal cell carcinomas.

Polish journal of pathology : official journal of the Polish Society of Pathologists·2016

Same author

PO-15 - Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1.

Thrombosis research·2016

Same author

[Immunohistochemical study of the role of mast cells and macrophages in the process of angiogenesis in the atherosclerotic plaques in patients with metabolic syndrome].

Arkhiv patologii·2016

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Targeting tumor lymphangiogenesis: an update.

M Raica¹, D Ribatti

¹Department of Histology and Cytology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

Current Medicinal Chemistry

|January 22, 2010

Summary

Tumor lymphangiogenesis, the formation of new lymphatic vessels in cancer, is crucial for metastasis. Understanding tumor lymphatic vessels aids in developing targeted therapies to inhibit cancer spread.

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Lymphatic metastasis is a common route for tumor spread.
Lymphovascular invasion is a predictor of lymph node metastasis.
Tumor lymphangiogenesis plays a critical role in cancer progression.

Purpose of the Study:

To review current literature on tumor lymphangiogenesis.
To address key questions regarding lymphatic endothelial cell markers, tumor lymphatic vessel characteristics, lymphangiogenic factors, and the role of lymphatic vessels in metastasis.
To explore the prognostic significance of lymphatic microvascular density and potential therapeutic inhibition strategies.

Main Methods:

Comprehensive literature review of recent research on lymphangiogenesis and tumor biology.

More Related Videos

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Related Experiment Videos

Last Updated: Jun 16, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Analysis of data concerning lymphatic endothelial cell markers and their specificity.

Evaluation of studies on the interplay of lymphangiogenic factors and the role of lymphatic vessels in tumor progression and metastasis.

Main Results:

Specific markers for lymphatic endothelial cells are being identified.
Tumor lymphatic vessels exhibit distinct characteristics compared to normal lymphatics.
Lymphangiogenic factors interact to promote vessel formation, contributing to metastasis and influencing prognosis.

Conclusions:

Tumor lymphangiogenesis is a complex process integral to cancer metastasis.
Understanding tumor lymphatic vessels offers potential therapeutic targets for inhibiting cancer spread.
Targeting lymphangiogenesis may represent a promising strategy for improving cancer patient outcomes.