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Related Experiment Video

Updated: Jun 16, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

imProving Outcomes after STroke clinical pilot trial protocol.

M L Hackett¹, G Carter, D Crimmins

¹Neurological and Mental Health Division, The George Institute for International Health, The University of Sydney and Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia. mhackett@george.org.au

International Journal of Stroke : Official Journal of the International Stroke Society

|January 22, 2010

Summary

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This study investigated if postcards can prevent depression in stroke patients. Early results will guide future large-scale trials on post-stroke depression prevention.

Area of Science:

Neurology
Psychiatry
Public Health

Background:

Post-stroke depression affects one in three patients, persisting over time.
A cost-effective, low-adverse event strategy is needed for depression prevention in stroke survivors.

Purpose of the Study:

To evaluate if a simple postcard intervention prevents depression in recent stroke patients.
To assess the intervention's impact on anxiety and health-related quality of life.

Main Methods:

A single-center, randomized, double-blind pilot trial involving patients within 8 weeks of stroke.
Participants received assessments plus either a postcard intervention or standard care.
Blinded telephone assessments measured mood, anxiety, and quality of life at baseline, 3, and 6 months.

Related Experiment Videos

Last Updated: Jun 16, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Main Results:

The study is powered to detect a significant reduction in depression incidence.
The sample size is designed to identify a 3-point difference in depression scores.

Conclusions:

The efficacy of this postcard intervention will determine the need for multi-center, international trials.
Positive findings could lead to a scalable strategy for post-stroke depression prevention.