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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Electron Transport Chain: Complex I and II01:46

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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Treatment Resistant Cancers02:56

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Treatment Resistent Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 16, 2026

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
06:19

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

Published on: May 12, 2020

Oxidative stress therapy for solid tumors - a proposal.

Mark F McCarty1, Jorge Barroso-Aranda, Francisco Contreras

  • 1Oasis of Hope Hospital, Playas de Tijuana, Tijuana, B.C. 22504, Mexico. mccarty@pantox.com

Medical Hypotheses
|January 22, 2010
PubMed
Summary
This summary is machine-generated.

This study proposes a novel cancer treatment strategy that increases oxidative stress in tumor cells. By combining oxidant-inducing agents with glucose deprivation and antioxidant defense suppression, researchers aim for selective tumor cell kill.

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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Area of Science:

  • Oncology
  • Biochemistry
  • Cancer Cell Biology

Background:

  • Many cancers exhibit reduced catalase activity, utilizing moderate oxidative stress for proliferation and survival.
  • Targeting cancer cell oxidative stress presents a potential therapeutic strategy.

Purpose of the Study:

  • To explore a multi-pronged strategy for selectively exacerbating oxidative stress in cancer cells.
  • To investigate methods for inducing tumor cell death by overwhelming antioxidant defenses.

Main Methods:

  • Induce oxidant production using sustained high-dose infusions of sodium ascorbate and menadione.
  • Impose glucose deprivation via 2-deoxyglucose or insulin clamp to inhibit antioxidant defenses.
  • Suppress hypoxia-inducible factor-1 (HIF-1) activity with agents like salicylate, rapamycin, and irinotecan.
  • Consider dichloroacetate to inhibit pyruvate dehydrogenase-1 and promote oxidative stress in hypoxic cells.

Main Results:

  • Proposed strategy aims to acutely exacerbate oxidative stress in cancer cells.
  • Combination therapy targets cancer's reliance on moderate oxidative stress.
  • Potential for selective tumor kill through combined interventions.

Conclusions:

  • A three-pronged approach combining oxidant induction, glucose deprivation, and HIF-1 suppression may selectively kill cancer cells.
  • Further research, starting with cell culture and progressing to animal and clinical trials, is warranted to validate this strategy.