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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...

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Related Experiment Video

Updated: Jun 16, 2026

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
09:13

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

PlasmoPredict: a gene function prediction website for Plasmodium falciparum.

Philip M R Tedder1, James R Bradford, Glenn A McConkey

  • 1Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

Trends in Parasitology
|January 22, 2010
PubMed
Summary
This summary is machine-generated.

Malaria parasite Plasmodium falciparum gene function remains largely unknown. PlasmoPredict is a new tool using genomics data to help identify functions for these unannotated Plasmodium falciparum genes.

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Last Updated: Jun 16, 2026

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Published on: December 4, 2015

Area of Science:

  • Genomics
  • Parasitology
  • Bioinformatics

Background:

  • The Plasmodium falciparum genome sequence, published in 2002, revealed approximately 60% of its genes lack assigned functions.
  • Despite advances, the majority of P. falciparum proteins remain functionally uncharacterized years later.

Purpose of the Study:

  • To present PlasmoPredict, an accessible online tool designed to predict gene function.
  • To aid in the annotation of uncharacterized genes in P. falciparum.

Main Methods:

  • Integration of diverse functional genomics data for P. falciparum.
  • Development of an easy-to-use online platform for gene function prediction.

Main Results:

  • PlasmoPredict provides a centralized resource for P. falciparum gene function prediction.
  • Facilitates the annotation process for a significant portion of the P. falciparum genome.

Conclusions:

  • PlasmoPredict addresses the critical need for functional annotation of P. falciparum genes.
  • The tool supports ongoing research into malaria parasite biology and potential therapeutic targets.