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Changes in corneal collagen architecture during mouse postnatal development.

Jack Sheppard¹, Sally Hayes, Craig Boote

¹School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom.

Investigative Ophthalmology & Visual Science

|January 22, 2010

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Corneal collagen arrangement changes significantly during mouse development, with interfibrillar spacing decreasing before eye opening and a specialized collagen annulus forming later, potentially influenced by vision.

Area of Science:

Ophthalmology
Developmental Biology
Biophysics

Background:

The cornea's transparency and structural integrity are crucial for vision.
Understanding corneal development is key to addressing developmental eye conditions.

Purpose of the Study:

To investigate the dynamic changes in corneal collagen arrangement during postnatal mouse development.
To correlate these structural changes with key developmental milestones like eye opening.

Main Methods:

Utilized small-angle and wide-angle X-ray scatter techniques on excised mouse corneas (postnatal days 10-28).
Analyzed collagen fibril separation distance, orientation, and distribution across the cornea and limbus.

Main Results:

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Corneal collagen interfibrillar spacing decreased significantly from day 10 to day 14, stabilizing thereafter.

Collagen orientation and distribution showed continuous changes, with increased alignment in the periphery and limbus after eye opening.

A distinct annulus of highly aligned collagen formed around the cornea by day 28.

Conclusions:

Postnatal corneal thickness changes are likely due to regional expansion/contraction of less organized collagen, not widespread fibrillar alterations.
The development of the corneal collagen annulus, important for curvature stability, may be visually triggered.