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Undernutrition & risk of infections in preschool children
Prema Ramachandran1, Hema S Gopalan
1Nutrition Foundation of India, New Delhi, India. premaramachandran@gmail.com
Insights
In Indian preschool children, low Body Mass Index (BMI) for age and wasting are more consistently linked to higher infection risk than stunting or underweight. Early intervention for energy deficits is crucial for reducing illness and supporting healthy growth.
Area of Science:
- Pediatric Nutrition
- Infectious Disease Epidemiology
- Public Health
Background:
- Undernutrition in preschool children is linked to immune suppression and increased infection risk, creating a detrimental cycle.
- In India, a significant proportion of children are underweight or stunted, with wasting also being a concern.
- Existing indicators like underweight may not fully capture the complex relationship between undernutrition and infection morbidity.
Purpose of the Study:
- To identify which anthropometric index of undernutrition best predicts infection-related morbidity in Indian preschool children.
- To compare the relative risk (RR) of infection morbidity across different indicators: weight-for-age, height-for-age, wasting, BMI-for-age, and combined wasting/stunting with low BMI.
- To inform public health strategies for addressing undernutrition and infection in young children.
Main Methods:
- Utilized data from 56,438 preschool children from the National Family Health Survey-3 (NFHS-3) in India.
- Calculated the relative risk (RR) of morbidity due to infections for children categorized by various undernutrition indices based on WHO 2006 standards.
- Included indicators such as stunting, underweight, low BMI-for-age, wasting, and a composite index of wasting and stunting with low BMI.
Main Results:
- Children with low Body Mass Index (BMI) for age and wasting exhibited a higher and more consistent relative risk of infection morbidity compared to those who were stunted or underweight.
- The highest relative risk of infection morbidity was observed in the subgroup of children experiencing both stunting and wasting.
- These findings highlight the significant association between indicators of acute energy deficit and infection susceptibility.
Conclusions:
- In Indian preschool children, low BMI-for-age and wasting are more reliable indicators of infection risk than traditional measures like weight-for-age and height-for-age.
- Low BMI-for-age and wasting signify current energy deficits, suggesting that prompt detection and management can mitigate infection risk.
- Addressing these specific nutritional deficits is vital for improving child health outcomes and ensuring continued healthy growth trajectories.
Background & Objective:
It is well documented that in preschool children undernutrition is associated with immune depression and increased risk of infections; infections aggravate undernutrition. Underweight is the most widely used indicator for assessment of undernutrition for investigating undernutrition and infection interactions. In India, nearly half the children are stunted and underweight; but majority of children have appropriate weight for their height and less than a fifth are wasted. The present study was undertaken to explore which of the five anthropometric indices for assessment of undernutrition (weight for age, height for age, wasting, BMI for age, and wasting and stunting with low BMI) is associated with more consistent and higher risk of morbidity due to infection in preschool children.
Methods:
The National Family Health Survey-3 (NFHS-3) database provided the following information in 56,438 preschool children: age, sex, weight, height, infant and young child feeding practices and morbidity due to infections in the last fortnight. Relative risk (RR) of morbidity due to infections was computed in infants and children with stunting, underweight, low BMI for age, wasting and stunting with low BMI (< mean-2SD of WHO 2006 standards).
Results:
Comparison of the RR for infections in undernourished children showed that the relative risk of morbidity due to infections was higher and more consistently seen in children with low BMI and wasting as compared to stunting or underweight. The small group of children who had stunting with wasting had the highest relative risk of morbidity due to infection.
Interpretation & Conclusion:
In Indian preschool children, RR for infection was more consistently associated with BMI for age and wasting as compared to weight for age and height for age. Low BMI for age and wasting indicate current energy deficit; early detection and correction of the current energy deficit might reduce the risk of infection and also enable the child to continue in his/her growth trajectory for weight and height.
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