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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jun 16, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Published on: February 15, 2022

Molecular complexity of primary open angle glaucoma: current concepts.

Kunal Ray1, Suddhasil Mookherjee

  • 1Molecular and Human Genetic Division, Indian Institute of Chemical Biology (a unit of CSIR), Kolkata, India. kunalray@gmail.com

Journal of Genetics
|January 22, 2010
PubMed
Summary

Primary open-angle glaucoma (POAG) has a complex genetic basis, but identified genes explain only a fraction of the disease. This study overviews potential mechanistic pathways involved in POAG pathogenesis.

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Last Updated: Jun 16, 2026

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

  • Ophthalmology
  • Genetics
  • Neuroscience

Background:

  • Glaucoma encompasses heterogeneous optic neuropathies with a significant genetic component.
  • Primary open-angle glaucoma (POAG) is the most prevalent subtype, with 25 linked loci identified but only three underlying genes discovered.
  • Despite strong genetic links, current genetic aberrations explain limited POAG pathogenesis.

Purpose of the Study:

  • To provide a mechanistic overview of potential pathways involved in POAG pathogenesis.
  • To explore the interplay and crosstalk between various factors contributing to POAG.
  • To enhance understanding of the multifactorial nature of POAG beyond genetics.

Main Methods:

  • Literature review and synthesis of current research on POAG pathogenesis.
  • Analysis of proposed etiological factors including mechanical stress, vascular, oxidative, excitotoxic, and immune responses.
  • Mechanistic overview of interconnected pathways.

Main Results:

  • Identified numerous genetic loci associated with POAG, yet a gap exists between genetic findings and disease explanation.
  • Highlighted multifactorial triggers for POAG, including intra-ocular pressure, reduced retinal blood flow, oxidative stress, and immune responses.
  • Detailed potential crosstalk between mechanical, vascular, and neurodegenerative pathways in POAG.

Conclusions:

  • POAG pathogenesis is a complex interplay of genetic and environmental factors, extending beyond identified genetic aberrations.
  • Understanding the crosstalk between various mechanistic pathways is crucial for a comprehensive view of POAG.
  • Further research into these interconnected pathways may reveal novel therapeutic targets for glaucoma treatment.