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A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
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Published on: January 19, 2024

Anaemia management in non-dialysis chronic kidney disease: flexibility of target to target stability?

Luca De Nicola1, Roberto Minutolo, Giuseppe Conte

  • 1Nephrology Division, Second University of Naples, Naples, Italy. luca.denicola@unina2.it

Nephron. Clinical Practice
|January 22, 2010
PubMed

International clinical practice guidelines have recently recognized for the first time the concrete difficulty of keeping chronic kidney disease (CKD) patients within the narrow haemoglobin (Hb) target recommended of 11-12 g/dl (110-120 g/l) because of the variability of individual patient Hb levels. This emerging clinical problem has been the topic of several editorials that, however, exclusively focused on haemodialysis patients. Recently, 3 retrospective studies have been published on Hb variability in non-dialysis CKD. The studies which overall included more than 6,000 patients showed that Hb variability in non-dialysis CKD is greatly prevalent and is associated with a worse cardiorenal outcome. This minireview summarizes the results and limits of these studies and discusses the potential implications for clinical practice.

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