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Related Experiment Video

Updated: Jun 16, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Homocysteine and cognitive function in geriatric depression.

P Alexopoulos¹, S Topalidis, G Irmisch

¹Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany. panos.alexopoulos @ lrz.tu-muenchen.de

Neuropsychobiology

|January 22, 2010

Summary

High homocysteine levels in geriatric depression patients correlated with better performance in language processing and processing speed, challenging previous assumptions about cognitive decline.

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Neuroscience
Gerontology
Psychiatry

Background:

Cognitive dysfunction is prevalent in geriatric depression.
Elevated homocysteine levels are associated with cognitive decline in neuropsychiatric conditions.

Purpose of the Study:

To investigate the association between cognitive impairment in geriatric depression and homocysteine levels.

Main Methods:

Assessed cognitive functions (language, processing speed, attention) in 40 geriatric depression patients and 25 healthy controls using Stroop and d2 tests.
Measured serum homocysteine levels via enzyme immunoassay.

Main Results:

Geriatric depression patients showed significantly poorer performance in language processing and processing speed.
Depressed patients with high homocysteine levels demonstrated better cognitive performance compared to those with lower levels.
Homocysteine levels positively correlated with language processing and processing speed.

Conclusions:

Homocysteine is positively associated with language processing and processing speed in geriatric depression.
Findings suggest a complex role for homocysteine in geriatric depression's cognitive symptoms, potentially linked to glutamatergic pathways.