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Risk factors for progression of chronic kidney disease

Amy Staples1, Craig Wong

  • 1Division of Pediatric Nephrology, Department of Pediatrics, University of New Mexico, Children's Hospital, Albuquerque, New Mexico, USA.

Current Opinion in Pediatrics
|January 22, 2010
PubMed

Insights

Identifying risk factors for chronic kidney disease (CKD) progression in children is crucial. Recent studies highlight lower kidney function, proteinuria, hypertension, and genetic factors as key indicators for disease advancement.

Area of Science:

  • Pediatric Nephrology
  • Genetics
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) progression in children presents unique challenges.
  • Understanding risk factors is vital for early intervention and management.
  • Recent advancements have refined the study of pediatric kidney failure.

Purpose of the Study:

  • To review identified risk factors for chronic kidney disease (CKD) progression.
  • To emphasize the specific context of the pediatric population.
  • To highlight recent changes in understanding and studying pediatric CKD.

Main Methods:

  • Review of recent literature and cohort studies in pediatric CKD.
  • Analysis of advancements in glomerular filtration rate (GFR) measurement and estimation equations.
  • Inclusion of findings from genome-wide association studies (GWAS).

Main Results:

  • Lower kidney function, elevated proteinuria, and hypertension are established markers for rapid GFR decline in pediatric CKD.
  • Anemia and other traditional risk factors require further validation.
  • GWAS have identified novel genetic loci associated with CKD progression.

Conclusions:

  • Mature pediatric CKD cohort studies are refining the assessment of disease progression.
  • Traditional risk factors remain important for evaluation.
  • Future research will focus on novel genetic risk factors identified through GWAS.
Abstract

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