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Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity
A Pompella1, A Romani, A Benedetti
1Istituto di Patologia Generale dell'Università di Siena, Italy.
Biochemical Pharmacology
|April 15, 1991
Abstract:
The data reported suggest that--following initiation of lipid peroxidation--membrane protein thiols can be attacked by lipid-derived radicals and/or reactive, lipid-soluble aldehydes like 4-hydroxynonenal and other hydroxyalkenals originated within the lipid core of cell membranes, resulting in a membrane protein thiol loss which is in turn associated with the development of hepatocellular injury.