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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

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Published on: December 3, 2020

Peptide aptamers against titanium-based implants identified through phage display.

Yan Liu¹, Jing Mao, Bin Zhou

¹Department of Stomatology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Journal of Materials Science. Materials in Medicine

|January 22, 2010

Summary

This summary is machine-generated.

Researchers identified novel peptide aptamers that strongly bind to commercially pure titanium (cp-Ti). These findings offer a new approach for functionalizing titanium implants in oral implantology.

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Last Updated: Jun 16, 2026

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Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

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Published on: April 11, 2020

Area of Science:

Biomaterials Science
Biotechnology
Oral Implantology

Background:

Commercially pure titanium (cp-Ti) is a standard material for long-term oral implants due to its osseointegration capabilities.
Enhancing cp-Ti implant functionality through biomimetic approaches, such as artificial proteins, is crucial for improved clinical outcomes.

Purpose of the Study:

To identify peptide aptamers with high affinity for cp-Ti surfaces using phage display.
To explore the potential of these aptamers for functional biomaterial coatings.

Main Methods:

Phage display methodology was employed for biopanning against cp-Ti disks.
Multiple rounds of selection and screening were performed to identify high-affinity peptide sequences.

Main Results:

Fifteen peptide sequences showed binding to cp-Ti after three rounds of biopanning.
The peptide aptamer TBP1 (ATWVSPY) demonstrated the strongest binding affinity and a high repetition rate (40% in round 3, 80% in round 4).
TBP2 (GVGLPHT) was also identified with a 20% repetition rate in round 4.

Conclusions:

Peptide aptamers, particularly TBP1, can be effectively selected for preferential adsorption to cp-Ti.
These identified peptide aptamers present a promising alternative for the functional coating of biomaterial surfaces in dental implants.