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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 16, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Promising new sources for pluripotent stem cells.

Christian Leeb1, Marcin Jurga, Colin McGuckin

  • 1Ludwig Boltzmann Institute for Cancer Research, Währingerstrasse 13A, Vienna, Austria.

Stem Cell Reviews and Reports
|January 22, 2010
PubMed
Summary

Stem cell research offers regenerative medicine potential but faces challenges. This review explores embryonic stem cells (ESCs) and alternatives like adult stem cells and induced pluripotent stem cells (iPS cells) for therapeutic use.

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Last Updated: Jun 16, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
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Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
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A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
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Area of Science:

  • Biomedical Sciences
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Embryonic stem cells (ESCs) advance understanding of cell plasticity and development.
  • ESCs hold promise for tissue repair and regenerative therapies.
  • Ethical concerns and tumor formation risks associated with ESCs necessitate exploring alternatives.

Purpose of the Study:

  • To review current findings on embryonic stem cells (ESCs).
  • To summarize therapeutic applications of ESCs.
  • To discuss alternatives to ESCs, including adult stem cells and induced pluripotent stem cells (iPS cells).

Main Methods:

  • Literature review of recent findings in stem cell research.
  • Analysis of therapeutic applications and potential of ESCs.
  • Comparative assessment of ESCs, adult stem cells, and iPS cells.

Main Results:

  • ESCs provide insights into developmental biology and cell plasticity.
  • Potential applications in regenerative medicine and tissue replacement are significant.
  • Adult stem cells and iPS cells offer alternative avenues with distinct advantages and challenges.

Conclusions:

  • Stem cell research, particularly ESCs, is pivotal in biomedical advancements.
  • Therapeutic applications are promising but require careful consideration of risks and ethics.
  • Exploring alternatives like adult stem cells and iPS cells is crucial for advancing regenerative medicine.