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Apparent hypocortisolism in an infant with prolonged hyperinsulinism
1Department of Pediatrics and Neonatology, Dr. Ram Manohar Lohia Hospital New Delhi, New Delhi, India. yzaygupta@gmail.com
Indian Journal of Pediatrics
|January 22, 2010
Summary
Transient hyperinsulinism with hypocortisolemia occurred in a preterm neonate experiencing recurrent hypoglycemia. Both conditions resolved spontaneously by the 22nd day of life.
Area of Science:
- Neonatal endocrinology
- Pediatric metabolic disorders
Background:
- Neonatal hypoglycemia is a common concern, particularly in preterm infants.
- Perinatal stress can impact neonatal endocrine function.
Observation:
- A preterm infant, small for gestational age, presented with recurrent hypoglycemia.
- Investigations revealed elevated insulin and low cortisol levels during hypoglycemic episodes.
Findings:
- The case demonstrated transient hyperinsulinism co-occurring with hypocortisolemia.
- Hormonal levels normalized, and hypoglycemia resolved spontaneously by day 22 of life.
Implications:
- This case highlights a rare presentation of transient endocrine dysfunction in neonates.
- Understanding such transient conditions is crucial for appropriate neonatal care and management.
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