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Apparent hypocortisolism in an infant with prolonged hyperinsulinism

Vijay Gupta1, V K Gupta

  • 1Department of Pediatrics and Neonatology, Dr. Ram Manohar Lohia Hospital New Delhi, New Delhi, India. yzaygupta@gmail.com

Indian Journal of Pediatrics
|January 22, 2010
PubMed

Insights

Transient hyperinsulinism with hypocortisolemia occurred in a preterm neonate experiencing recurrent hypoglycemia. Both conditions resolved spontaneously by the 22nd day of life.

Area of Science:

  • Neonatal endocrinology
  • Pediatric metabolic disorders

Background:

  • Neonatal hypoglycemia is a common concern, particularly in preterm infants.
  • Perinatal stress can impact neonatal endocrine function.

Observation:

  • A preterm infant, small for gestational age, presented with recurrent hypoglycemia.
  • Investigations revealed elevated insulin and low cortisol levels during hypoglycemic episodes.

Findings:

  • The case demonstrated transient hyperinsulinism co-occurring with hypocortisolemia.
  • Hormonal levels normalized, and hypoglycemia resolved spontaneously by day 22 of life.

Implications:

  • This case highlights a rare presentation of transient endocrine dysfunction in neonates.
  • Understanding such transient conditions is crucial for appropriate neonatal care and management.

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