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The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

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Interventions for acute otitis externa.

Vivek Kaushik¹, Tass Malik, Shakeel R Saeed

¹Department of Otolaryngology, Head & Neck Surgery, Stockport NHS Foundation Trust, Stepping Hill Hospital, Poplar Grove, Hazel Grove, Stockport, UK, SK2 7JE.

The Cochrane Database of Systematic Reviews

|January 22, 2010

Summary

This summary is machine-generated.

Topical treatments are effective for acute otitis externa (swimmer's ear), with most providing similar outcomes. Antibiotic/steroid drops offer symptom relief within six days, but individualized treatment duration is recommended.

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Area of Science:

Otolaryngology
Dermatology
Infectious Diseases

Background:

Acute otitis externa (AOE), or swimmer's ear, is a common inflammatory condition of the ear canal.
Symptoms include discomfort, itching, discharge, and hearing impairment.

Purpose of the Study:

To assess the effectiveness of various interventions for acute otitis externa.

Main Methods:

Systematic review of 19 randomized controlled trials (RCTs) involving 3382 participants.
Included trials evaluated ear cleaning, topical, or systemic therapies for AOE.
Excluded complicated cases, secondary infections, chronic, fungal, eczematous, or viral otitis externa, and furunculosis.

Main Results:

Topical antimicrobials with steroids were more effective than placebo drops (OR 11).
Most topical treatments showed no significant clinical cure rate differences, except acetic acid, which was less effective than antibiotic/steroid drops.
No trials evaluated ear cleaning; evidence for steroid-only drops was limited.

Conclusions:

High-quality evidence for AOE interventions is limited, with most findings based on single trials.
Topical treatments are effective for uncomplicated AOE, with intervention choice often based on factors beyond efficacy.
Individualized treatment duration for ear drops is recommended, with persistent symptoms indicating potential treatment failure.