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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Blood transfusions for treating acute chest syndrome in people with sickle cell disease

Dunia Alhashimi1, Zbys Fedorowicz, Fatima Alhashimi

  • 1Paediatrics, Salmaniya Medical Complex, Box 12, Manama, Bahrain.

The Cochrane Database of Systematic Reviews
|January 22, 2010
PubMed

Insights

Currently, no studies confirm if blood transfusions effectively treat acute chest syndrome (ACS) in sickle cell disease (SCD). More research is needed to determine the benefits and risks of transfusions for ACS in SCD patients.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Clinical Trials

Background:

  • Sickle cell disease (SCD) is a prevalent inherited blood disorder globally.
  • Acute chest syndrome (ACS) is a life-threatening complication of SCD, particularly in children.
  • Standard ACS treatment includes hydration, oxygen, antibiotics, and potentially blood transfusions.

Purpose of the Study:

  • To evaluate the efficacy of simple and exchange blood transfusions for treating ACS.
  • To compare transfusion effectiveness against standard care for symptom improvement and clinical outcomes.

Main Methods:

  • Searched the Haemoglobinopathies Trials Register for relevant studies.
  • Included randomized and quasi-randomized controlled trials.
  • Focused on comparisons of transfusion versus standard care for ACS in SCD.

Main Results:

  • No eligible studies were identified for inclusion in this review.
  • There is a lack of empirical data on the effectiveness of blood transfusions for ACS in SCD.

Conclusions:

  • No reliable evidence currently supports or refutes blood transfusions for ACS in SCD.
  • High-quality randomized controlled trials are necessary to establish the benefits and risks of transfusion therapy for ACS in SCD.
Abstract

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