Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

Biosynthesis in Bacteria

Biosynthesis in Bacteria

Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...

Assembly of Cytoskeletal Filaments

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A minimally invasive, scalable and reproducible neonatal rat model of severe focal brain injury.

Brain communications·2026

Same author

Water-Mediated Reconfigurable Topology and Mechanics in Porous Peptide Materials.

Matter·2026

Same author

Backbone-Constrained Tripeptides Enable Sequence Control of Solid-State Dynamics.

Angewandte Chemie (International ed. in English)·2026

Same author

Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients.

Chem·2026

Same author

Renovating Neural Networks With Viral-Mediated Gene Transfer From A Tissue Contacting Matrix Mimic.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Staying one step ahead of chronic wounds by designing symbiotic, responsive functionality into dynamic nanohydrogels.

Journal of materials chemistry. B·2025

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Exploiting biocatalysis in peptide self-assembly.

Richard J Williams¹, Robert J Mart, Rein V Ulijn

¹CSIRO Molecular and Health Technologies, Bayview Avenue, Clayton South, VIC 3169, Australia.

|January 22, 2010

Summary

This summary is machine-generated.

Enzyme-assisted self-assembly (e-SA) uses biocatalysis to create molecular building blocks for controlled nanomaterial fabrication. This method enhances control over self-assembly processes, leading to more complex and defect-free nanostructures.

More Related Videos

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Related Experiment Videos

Last Updated: Jun 16, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Area of Science:

Biomaterials Science
Nanotechnology
Biocatalysis

Background:

Molecular self-assembly (SA) is a key process in soft materials.
Enzyme-catalyzed reactions offer high selectivity.
Combining biocatalysis with SA presents new opportunities in nanofabrication.

Purpose of the Study:

To review recent developments in enzyme-assisted self-assembly (e-SA).
To explore the molecular design principles for e-SA precursors.
To discuss the applications and unique features of e-SA systems.

Main Methods:

Enzyme-catalyzed production of molecular building blocks from nonassembling precursors.
Utilizing noncovalent interactions for ordered structure formation.
Designing SA precursors with enzyme recognition, molecular switching, and supramolecular interaction components.

Main Results:

e-SA enables precise control over nucleation and structure growth.
Systems exhibit tunable mechanical properties and defect correction capabilities.
Thermodynamic control allows for component selection in self-assembly.

Conclusions:

e-SA offers unprecedented control over self-assembly processes.
This approach facilitates the production of complex, low-defect nanostructures.
e-SA has broad applications in biomedicine and bio(nano)technology.