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An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Virtual patient simulator for the perfusion resource management drill.
Shinji Ninomiya1, Megumi Tokaji, Asako Tokumine
1Department of Clinical Engineering, Hiroshima International University, Hiroshima, Japan. s-nino@hs.hirokoku-u.ac.jp
The Journal of Extra-Corporeal Technology
|January 23, 2010
Summary
A new perfusion simulator system (ECCSIM) enhances training for extracorporeal circulation. This hybrid simulator accurately models patient physiology, improving perfusionist skills in managing complex procedures.
Area of Science:
- Biomedical Engineering
- Medical Simulation
- Cardiovascular Technology
Background:
- Perfusionists need expertise in patient physiology and cardiopulmonary bypass systems.
- Practical skills in extracorporeal circulation (ECC) technology are crucial for effective training.
- Educational simulators offer a safe environment for developing these essential skills.
Purpose of the Study:
- To design and evaluate a novel perfusion simulator system (ECCSIM) for training.
- To create a hybrid system combining hydraulic mock circulation with computer modeling.
- To assess the system's ability to reproduce physiological conditions and aid skill development.
Main Methods:
- Developed ECCSIM, a hybrid system integrating a hydraulic mock circulation loop and a computer simulation model.
- Utilized parameter estimation to determine patient physiological conditions (height, weight, cardiac indices).
- Reproduced hemodynamic conditions accurately for realistic training scenarios.
Main Results:
- Trainees successfully maintained venous oxygen saturation above 50% during simulated procedures.
- The system demonstrated increased infant physiological parameter amplitudes compared to adults.
- Instructors could adjust difficulty by modifying hemodynamic variations, enhancing training adaptability.
Conclusions:
- High-fidelity perfusion simulators with adjustable difficulty are valuable for training.
- ECCSIM provides a reproducible and adaptable environment for perfusionist education.
- The simulator facilitates basic training and crisis management drills in perfusion resource management.

