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Updated: Jun 16, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Measurement of long-range interatomic distances by solid-state tritium-NMR spectroscopy
Alexander K L Yuen1, Olivier Lafon, Thibault Charpentier
1CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, F-91191 Gif sur Yvette, France.
Abstract:
For the structural determination of a ligand bound to an amorphous macromolecular system, solid-state NMR can be used to provide interatomic distances. It is shown here that selective labeling in discrete locations with tritium enables accurate measurement of long-range distances owing to the high gyromagnetic ratio of this nucleus, without structural modification of the molecule. This approach gives access to the largest NMR distance ever measured between two nuclei (14.4 A). (3)H MAS NMR appears to be a promising tool for structural applications in the biological and material sciences.
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