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Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to

Tomohiro Osanai1, Naoto Fujiwara, Satoko Sasaki

  • 1Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. osanait@cc.hirosaki-u.ac.jp

Annals of Medicine
|January 23, 2010
PubMed

Insights

Coupling factor 6 (CF6) is elevated in stroke patients and linked to homocysteine (Hcy) levels. Vitamin treatment reduced both CF6 and Hcy, suggesting CF6

Area of Science:

  • Biochemistry
  • Neurology
  • Cardiovascular Research

Background:

  • Homocysteine (Hcy) is a known stroke predictor.
  • Nuclear factor kappa B (NF-kappaB) signaling, activated by Hcy, regulates Coupling Factor 6 (CF6).

Purpose of the Study:

  • To investigate if CF6 levels are elevated in stroke patients.
  • To examine the impact of vitamin treatment on CF6 and Hcy levels in stroke.

Main Methods:

  • A study involving 59 Japanese stroke patients, randomly assigned to vitamin treatment (folic acid and B12) or no treatment.
  • Plasma CF6 and total homocysteine (tHcy) levels were measured at admission and after 2 months.

Main Results:

  • CF6 levels were higher in stroke patients compared to controls.
  • Plasma CF6 and tHcy levels decreased in the vitamin-treated group, showing a weak positive correlation.
  • No significant changes in CF6 or tHcy were observed in the untreated group.

Conclusions:

  • CF6 is elevated in stroke patients, independent of other risk factors.
  • CF6 may play a role in stroke development and presents a potential therapeutic target.
  • Vitamin treatment impacts CF6 levels, highlighting its potential in stroke management.
Abstract

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